| Pitchers | Team | IP |
| Strider, Spencer | ATL | 131.7 |
| Greene, Hunter | CIN | 125.7 |
| Lodolo, Nick | CIN | 103.3 |
| Schreiber, John | BOS | 65.0 |
| Robertson, David | CHC / PHI | 63.7 |
| Adam, Jason | TBR | 63.3 |
| Phillips, Evan | LAD | 63.0 |
| Beeks, Jalen | TBR | 61.0 |
| Effross, Scott | CHC / NYY | 56.7 |
| Wilson, Steven | SDP | 53.0 |
| Lee, Dylan | ATL | 50.7 |
| Suarez, Robert | SDP | 47.7 |
| Pallante, Andre | STL | 108.0 |
| Martinez, Nick | SDP | 106.3 |
| Contreras, Roansy | PIT | 95.0 |
| Sears, JP | NYY / OAK | 70.0 |
| Gore, MacKenzie | SDP | 70.0 |
| Puk, A.J. | OAK | 66.3 |
| Diaz, Alexis | CIN | 63.7 |
| Edwards Jr., Carl | WSN | 62.0 |
| Hughes, Brandon | CHC | 57.7 |
| Bellatti, Andrew | PHI | 54.3 |
| Elder, Bryce | ATL | 54.0 |
| Stephens, Jackson | ATL | 53.7 |
| Jackson, Zach | OAK | 48.0 |
| Farmer, Buck | CIN | 47.0 |
| Harvey, Hunter | WSN | 39.3 |
| Martinez, Seth | HOU | 38.7 |
| Nelson, Kyle | ARI | 37.0 |
| Overton, Connor | CIN | 33.0 |
| Wesneski, Hayden | CHC | 33.0 |
| Baz, Shane | TBR | 27.0 |
| Ashcraft, Graham | CIN | 105.0 |
| Nelson, Nick | PHI | 68.7 |
| Acevedo, Domingo | OAK | 67.7 |
| Leiter, Mark | CHC | 67.7 |
| Armstrong, Shawn | MIA / TBR | 61.7 |
| Poche, Colin | TBR | 58.7 |
| Bello, Brayan | BOS | 57.3 |
| Moll, Sam | OAK | 43.3 |
| Pepiot, Ryan | LAD | 36.3 |
| Strzelecki, Peter | MIL | 35.0 |
| Liberatore, Matthew | STL | 34.7 |
| Waldichuk, Ken | OAK | 34.7 |
| Thompson, Zack | STL | 34.7 |
| Jimenez, Dany | OAK | 34.3 |
| Naughton, Packy | STL | 32.0 |
| Mills, Wyatt | SEA / KC | 29.3 |
| Holderman, Colin | PIT | 28.3 |
| Minor, Mike | CIN | 98.0 |
| Feltner, Ryan | COL | 97.3 |
| Crawford, Kutter | BOS | 77.3 |
| Oller, Adam | OAK | 74.3 |
| Alexander, Jason | MIL | 71.7 |
| Winckowski, Josh | BOS | 70.3 |
| Sanchez, Anibal | WSN | 69.3 |
| Adon, Joan | WSN | 64.7 |
| Brasier, Ryan | BOS | 62.3 |
| Keuchel, Dallas | ARI / TEX | 60.7 |
| Bush, Matt | TEX / MIL | 59.7 |
| Kuhnel, Joel | CIN | 58.0 |
| Stephenson, Robert | COL / PIT | 58.0 |
| Martinez, Adrian | OAK | 57.7 |
| Logue, Zach | OAK | 57.0 |
| Sanmartin, Reiver | CIN | 57.0 |
| Davis, Austin | BOS / MIN | 56.0 |
| Pruitt, Austin | OAK | 55.3 |
| Mayers, Mike | LAA | 50.7 |
| Abbott, Cory | WSN | 48.0 |
| Marte, Yunior | SFG | 48.0 |
| Bird, Jake | COL | 47.7 |
| Chacin, Jhoulys | COL | 47.3 |
| Henry, Tommy | ARI | 47.0 |
| Colome, Alex | COL | 47.0 |
| Gott, Trevor | MIL | 45.7 |
| Snead, Kirby | OAK | 44.7 |
| Hoffman, Jeff | CIN | 44.7 |
| Blach, Ty | COL | 44.3 |
| Castellanos, Humberto | ARI | 44.3 |
| Lawrence, Justin | COL | 42.7 |
| Arano, Victor | WSN | 42.0 |
| Banuelos, Manny | NYY / PIT | 41.0 |
| Danish, Tyler | BOS | 40.3 |
| Sanchez, Christopher | PHI | 40.0 |
| Jefferies, Daulton | OAK | 39.3 |
| Koenig, Jared | OAK | 39.3 |
| Moreta, Dauri | CIN | 38.3 |
| Assad, Javier | CHC | 37.7 |
| McGee, Jake | MIL / WSH | 37.0 |
| Gutierrez, Vladimir | CIN | 36.7 |
| Gibaut, Ian | CIN | 36.0 |
| Warren, Art | CIN | 36.0 |
| Castano, Daniel | MIA | 35.7 |
| Garza, Ralph | TBR | 35.0 |
| Ortega, Oliver | LAA | 34.0 |
| Swarmer, Matt | CHC | 34.0 |
| Sulser, Cole | MIA | 34.0 |
| McFarland, T.J. | STL | 32.7 |
| Brazoban, Huascar | MIA | 32.0 |
| Grove, Michael | LAD | 29.3 |
| Wittgren, Nick | STL | 29.0 |
| Misiewicz, Anthony | SEA / KC | 29.0 |
| Silseth, Chase | LAA | 28.7 |
| Poppen, Sean | ARI | 28.7 |
| Ort, Kaleb | BOS | 28.3 |
| Newcomb, Sean | ATL / CHC | 27.7 |
| Uelmen, Erich | CHC | 27.0 |
| Banda, Anthony | TOR / NYY / PIT | 26.7 |
| Young, Alex | CLE / SF | 26.7 |
| De Los Santos, Yerry | PIT | 25.7 |
| Borucki, Ryan | TOR / SEA | 25.3 |
| Hjelle, Sean | SFG | 25.0 |
| Hunter, Tommy | NYM | 22.3 |
| Sulser, Beau | PIT / BAL | 22.3 |
| Milner, Hoby | MIL | 64.7 |
| Dominguez, Seranthony | PHI | 51.0 |
| Wick, Rowan | CHC | 64.0 |
| Nance, Tommy | MIA | 43.7 |
| Weems, Jordan | WSN | 39.7 |
| Herget, Jimmy | LAA | 69.0 |
| Stratton, Chris | PIT / STL | 63.3 |
| Sanchez, Aaron | WSH / MIN | 60.0 |
| Detwiler, Ross | CIN | 26.3 |
| Watkins, Spenser | BAL | 105.3 |
| Brebbia, John | SFG | 68.0 |
| De Jong, Chase | PIT | 71.7 |
| Lamet, Dinelson | SDP / COL | 32.3 |
| Shreve, Chasen | NYM | 26.3 |
| Fleming, Josh | TBR | 35.0 |
| Rainey, Tanner | WSN | 30.0 |
| Kinley, Tyler | COL | 24.0 |
| Kirby, George | SEA | 130.0 |
| Bradish, Kyle | BAL | 117.7 |
| Baker, Bryan | BAL | 69.7 |
| Diekman, Jake | BOS / CHW | 57.7 |
| Voth, Austin | WSH / BAL | 101.7 |
| Hand, Brad | PHI | 45.0 |
| Gilbreath, Lucas | COL | 43.0 |
| Ginkel, Kevin | ARI | 29.3 |
| Garrett, Braxton | MIA | 88.0 |
| Estevez, Carlos | COL | 57.0 |
| Bleier, Richard | MIA | 50.7 |
| Weaver, Luke | ARI / KC | 35.7 |
| Rogers, Josh | WSN | 26.3 |
| Head, Louis | MIA / BAL | 28.7 |
| May, Trevor | NYM | 25.0 |
| Gilbert, Tyler | ARI | 34.3 |
| Brigham, Jeff | MIA | 24.0 |
| Goudeau, Ashton | COL | 20.3 |
| Blackburn, Paul | OAK | 111.3 |
| Bickford, Phil | LAD | 61.0 |
| Almonte, Yency | LAD | 35.3 |
| Gonzalez, Chi Chi | MIN / MIL / NYY | 23.0 |
| Rucker, Michael | CHC | 54.7 |
| Strahm, Matt | BOS | 44.7 |
| Moronta, Reyes | LAD / ARI | 37.7 |
| Leone, Dominic | SFG | 49.3 |
| Gustave, Jandel | MIL | 28.0 |
| Beede, Tyler | SFG / PIT | 61.3 |
| Kennedy, Ian | ARI | 50.3 |
| Familia, Jeurys | PHI / BOS | 44.3 |
| Peters, Dillon | PIT | 39.3 |
| Poteet, Cody | MIA | 28.0 |
| Robles, Hansel | BOS | 24.7 |
| Hembree, Heath | PIT / LAD | 22.0 |
| Zimmermann, Bruce | BAL | 73.7 |
| Bautista, Felix | BAL | 65.7 |
| Krehbiel, Joey | BAL | 57.7 |
| Trivino, Lou | OAK / NYY | 53.7 |
| Brash, Matt | SEA | 50.7 |
| Littell, Zack | SFG | 44.3 |
| Vespi, Nick | BAL | 26.3 |
| Kremer, Dean | BAL | 125.3 |
| Murfee, Penn | SEA | 69.3 |
| Perez, Cionel | BAL | 57.7 |
| Festa, Matthew | SEA | 54.0 |
| Ramirez, Noe | ARI | 50.0 |
| Baumann, Mike | BAL | 34.3 |
| Otto, Glenn | TEX | 135.7 |
| Heasley, Jon | KCR | 104.0 |
| Burke, Brock | TEX | 82.3 |
| Brieske, Beau | DET | 81.7 |
| Coleman, Dylan | KCR | 68.0 |
| Duran, Jhoan | MIN | 67.7 |
| Winder, Josh | MIN | 67.0 |
| Richards, Trevor | TOR | 64.0 |
| Phelps, David | TOR | 63.7 |
| Martin, Davis | CHW | 63.3 |
| Vest, Will | DET | 63.0 |
| Foley, Jason | DET | 60.3 |
| Hill, Garrett | DET | 60.3 |
| Pilkington, Konnor | CLE | 58.0 |
| Schmidt, Clarke | NYY | 57.7 |
| Jimenez, Joe | DET | 56.7 |
| Faedo, Alex | DET | 53.7 |
| De Los Santos, Enyel | CLE | 53.3 |
| Banks, Tanner | CHW | 53.0 |
| Garcia, Rony | DET | 51.0 |
| Leclerc, Jose | TEX | 47.7 |
| Lambert, Jimmy | CHW | 47.0 |
| Pineda, Michael | DET | 46.7 |
| Garrett, Amir | KCR | 45.3 |
| Foster, Matt | CHW | 45.0 |
| Megill, Trevor | MIN | 45.0 |
| Sandlin, Nick | CLE | 44.0 |
| Marinaccio, Ron | NYY | 44.0 |
| Richards, Garrett | TEX | 42.7 |
| Moran, Jovani | MIN | 40.7 |
| Ragans, Cole | TEX | 40.0 |
| Castillo, Max | TOR / KC | 39.3 |
| Abreu, Albert | KCR / NYY | 38.7 |
| Peralta, Wily | DET | 38.3 |
| Cuas, Jose | KCR | 37.7 |
| McCarty, Kirk | CLE | 37.7 |
| Staumont, Josh | KCR | 37.7 |
| Chapman, Aroldis | NYY | 36.3 |
| Snider, Collin | KCR | 34.3 |
| Wentz, Joey | DET | 32.7 |
| Sands, Cole | MIN | 30.7 |
| Hernandez, Jonathan | TEX | 30.3 |
| Rodriguez, Elvin | DET | 29.7 |
| Smith, Joe | MIN | 27.3 |
| Ryu, Hyun-Jin | TOR | 27.0 |
| Merryweather, Julian | TOR | 26.7 |
| Bummer, Aaron | CHW | 26.7 |
| Varland, Louie | MIN | 26.0 |
| Jameson, Drey | ARI | 24.3 |
| Yajure, Miguel | PIT | 24.3 |
| Anderson, Chase | CIN | 24.0 |
| Bruihl, Justin | LAD | 23.7 |
| Kelley, Trevor | MIL | 23.7 |
| Medina, Adonis | NYM | 23.7 |
| Perdomo, Luis | MIL | 23.7 |
| Morris, Cody | CLE | 23.7 |
| Cleavinger, Garrett | LAD / TB | 23.0 |
| Martin, Corbin | ARI | 22.3 |
| Stout, Eric | CHC / PIT | 22.3 |
| Barnes, Jacob | DET / NYY | 22.3 |
| Sborz, Josh | TEX | 22.3 |
| Nogosek, Stephen | NYM | 22.0 |
| O'Day, Darren | ATL | 21.7 |
| VerHagen, Drew | STL | 21.7 |
| Faucher, Calvin | TBR | 21.3 |
| Tetreault, Jackson | WSN | 21.0 |
| Gose, Anthony | CLE | 21.0 |
| Tinoco, Jesus | TEX | 20.7 |
| Brown, Hunter | HOU | 20.3 |
| Sousa, Bennett | CHW | 20.3 |
| Arihara, Kohei | TEX | 20.0 |
| Santillan, Tony | CIN | 19.7 |
| Law, Derek | DET / CIN | 19.7 |
| Batters | Team | AB |
| Harris II, Michael | ATL | 414 |
| Donovan, Brendan | STL | 391 |
| Pena, Jeremy | HOU | 521 |
| Carroll, Corbin | ARI | 104 |
| Cruz, Oneil | PIT | 331 |
| Suzuki, Seiya | CHC | 397 |
| Bethancourt, Cristian | OAK / TB | 318 |
| Abrams, CJ | SD / WSH | 284 |
| Grissom, Vaughn | ATL | 141 |
| Perdomo, Geraldo | ARI | 431 |
| Stott, Bryson | PHI | 427 |
| Thomas, Alek | ARI | 381 |
| Paredes, Isaac | TBR | 331 |
| Gorman, Nolan | STL | 283 |
| Yepez, Juan | STL | 253 |
| Meneses, Joey | WSN | 222 |
| Casas, Triston | BOS | 76 |
| Bouchard, Sean | COL | 74 |
| Mitchell, Garrett | MIL | 61 |
| Morel, Christopher | CHC | 379 |
| Gonzalez, Luis | SFG | 311 |
| Allen, NIck | OAK | 299 |
| Thompson, Trayce | SDP/ LAD | 219 |
| Lowe, Josh | TBR | 181 |
| Leblanc, Charles | MIA | 156 |
| Brujan, Vidal | TBR | 147 |
| Langeliers, Shea | OAK | 142 |
| Toglia, Michael | COL | 111 |
| Steer, Spencer | CIN | 95 |
| Groshans, Jordan | MIA | 61 |
| Rivera, Emmanuel | KC / ARI | 330 |
| Suwinski, Jack | PIT | 326 |
| Velazquez, Andrew | LAA | 322 |
| Neuse, Sheldon | OAK | 271 |
| Schwindel, Frank | CHC | 271 |
| Rosario, Eddie | ATL | 250 |
| Reynolds, Matt | CIN | 244 |
| Cordero, Franchy | BOS (to Bal) | 242 |
| Friedl, T.J. | CIN | 225 |
| Gregorius, Didi | PHI | 214 |
| Mitchell, Calvin | PIT | 212 |
| Vargas, Ildemaro | CHC / WSH | 209 |
| Bleday, JJ | MIA | 204 |
| Azocar, Jose | SDP | 202 |
| Serven, Brian | COL | 187 |
| Velazquez, Nelson | CHC | 185 |
| Herrera, Odubel | PHI | 185 |
| La Stella, Tommy | SFG | 180 |
| Hummel, Cooper | ARI | 176 |
| Montero, Elehuris | COL | 176 |
| VanMeter, Josh | PIT | 171 |
| Tsutsugo, Yoshi | PIT | 170 |
| Chang, Yu | TBR / BOS | 168 |
| Clement, Ernie | CLE / OAK | 163 |
| Bride, Jonah | OAK | 162 |
| Mazara, Nomar | SDP | 159 |
| Heineman, Tyler | TOR / PIT | 157 |
| Villar, David | SFG | 156 |
| Delay, Jason | PIT | 155 |
| Camargo, Johan | PHI | 152 |
| Lopez, Alejo | CIN | 145 |
| Smith, Kevin | OAK | 139 |
| Hall, Darick | PHI | 136 |
| Ford, MIke | SEA / ATL / LAA | 131 |
| Mercado, Oscar | CLE / PHI | 121 |
| Allen, Greg | PIT | 118 |
| Garcia, Dermis | OAK | 116 |
| Call, Alex | CLE / WSH | 114 |
| Madris, Bligh | PIT | 113 |
| Beer, Seth | ARI | 111 |
| Herrera, Jose | ARI | 111 |
| Bolt, Skye | OAK | 106 |
| Moniak, Mickey | PHI / LAA | 106 |
| Zimmer, Bradley | PHI / TOR | 105 |
| Cano, Robinson | NYM / SDP / ATL | 100 |
| Lamb, Jake | LAD / SEA | 97 |
| Fairchild, Stuart | SEA / SFG / CIN | 97 |
| Collins, Zack | TOR / PIT | 97 |
| Adrianza, Ehire | WSH / ATL | 97 |
| Burdick, Peyton | MIA | 92 |
| Papierski, Michael | SFG / CIN | 91 |
| Demeritte, Travis | ATL | 89 |
| Kennedy, Buddy | ARI | 83 |
| Pinto, Rene | TBR | 80 |
| Aranda, Jonathan | TBR | 78 |
| Barrera, Luis | OAK | 77 |
| Encarnacion, Jerar | MIA | 77 |
| Garrett, Stone | ARI | 76 |
| Walton, Donovan | SEA / SFG | 76 |
| Davis, Jonathan | MIL | 76 |
| Heredia, Guillermo | ATL | 76 |
| Simmons, Andrelton | CHC | 75 |
| Gosselin, Phil | ATL / LAA | 74 |
| Mercedes, Yermin | SFG | 73 |
| Duggar, Steven | SFG / TEX / LAA | 72 |
| Mayfield, Jack | LAA | 70 |
| Thaiss, Matt | LAA | 69 |
| Matijevic, J.J. | HOU | 67 |
| Hermosillo, Michael | CHC | 61 |
| Stefanic, Michael | LAA | 61 |
| Stevenson, Cal | OAK | 60 |
| Robinson, Chuckie | CIN | 59 |
| Strange-Gordon, Dee | WSN | 59 |
| Rojas, Jose | LAA | 56 |
| Owings, Chris | BAL | 56 |
| Soto, Livan | LAA | 55 |
| Astudillo, Willians | MIA | 54 |
| Capel, Connor | STL / OAK | 52 |
| Calhoun, Willie | TEX / SFG | 52 |
| MacKinnon, David | LAA / OAK | 50 |
| Hager, Jake | ARI | 50 |
| Upton, Justin | SEA | 48 |
| Goodrum, Niko | HOU | 43 |
| Almora Jr., Albert | CIN | 215 |
| Barrera, Tres | WSN | 50 |
| Machin, Vimael | OAK | 223 |
| Duffy, Matt | LAA | 228 |
| Higgins, P.J. | CHC | 201 |
| Lagares, Juan | LAA | 60 |
| McKinney, Billy | OAK | 52 |
| DeJong, Paul | STL | 210 |
| Fortes, Nick | MIA | 217 |
| Barrero, Jose | CIN | 165 |
| Brosseau, Mike | MIL | 141 |
| Marisnick, Jake | PIT | 77 |
| Dickerson, Corey | STL | 281 |
| Stubbs, Garrett | PHI | 106 |
| Rodriguez, Julio | SEA | 511 |
| Henderson, Gunnar | BAL | 116 |
| Stowers, Kyle | BAL | 91 |
| Vavra, Terrin | BAL | 89 |
| Bemboom, Anthony | BAL | 52 |
| Meyers, Jake | HOU | 150 |
| Mathias, Mark | MIL / TEX | 81 |
| Quinn, Roman | PHI / TBR | 79 |
| Lowrie, Jed | OAK | 167 |
| Mazeika, Patrick | NYM | 68 |
| Munoz, Yairo | PHI | 57 |
| Ruf, Darin | SF / NYM | 334 |
| Piscotty, Stephen | OAK | 126 |
| Jankowski, Travis | SEA / NYM | 55 |
| Hampson, Garrett | COL | 199 |
| Vogt, Stephen | OAK | 168 |
| Perez, Michael | PIT / NYM | 121 |
| Diaz, Lewin | MIA | 160 |
| Rios, Edwin | LAD | 86 |
| Cain, Lorenzo | MIL | 145 |
| Vosler, Jason | SFG | 98 |
| Castro, Jason | HOU | 78 |
| Garcia, Aramis | CIN | 108 |
| Vogelbach, Daniel | PIT / NYM | 386 |
| Arcia, Orlando | ATL | 209 |
| Trejo, Alan | COL | 118 |
| Heyward, Jason | CHC | 137 |
| Raley, Luke | TBR | 61 |
| Rutschman, Adley | BAL | 398 |
| Chirinos, Robinson | BAL | 195 |
| Hilliard, Sam | COL | 174 |
| Nevin, Tyler | BAL | 157 |
| McKenna, Ryan | BAL | 156 |
| Witt Jr., Bobby | KCR | 591 |
| Haggerty, Sam | SEA | 176 |
| Marcano, Tucupita | PIT | 160 |
| Tucker, Cole | PIT | 63 |
| Kwan, Steven | CLE | 563 |
| Melendez, MJ | KCR | 460 |
| Miranda, Jose | MIN | 444 |
| Greene, Riley | DET | 376 |
| Gonzalez, Oscar | CLE | 362 |
| Torkelson, Spencer | DET | 360 |
| Pasquantino, Vinnie | KCR | 258 |
| Miller, Brad | TEX | 222 |
| Smith, Josh | TEX | 213 |
| Duran, Ezequiel | TEX | 208 |
| Gonzalez, Marwin | NYY | 184 |
| Maile, Luke | CLE | 181 |
| Massey, Michael | KCR | 173 |
| Thompson, Bubba | TEX | 170 |
| Cave, Jake | MIN | 164 |
| Pratto, Nick | KCR | 158 |
| Cabrera, Oswaldo | NYY | 154 |
| Garlick, Kyle | MIN | 150 |
| O'Hearn, Ryan | KCR | 134 |
| Carpenter, Matt | NYY | 128 |
| Ibanez, Andy | TEX | 119 |
| Clemens, Kody | DET | 117 |
| Palacios, Richie | CLE | 112 |
| Eaton, Nate | KCR | 106 |
| Gonzalez, Romy | CHW | 105 |
| Carpenter, Kerry | DET | 103 |
| Jung, Josh | TEX | 98 |
| Mendick, Danny | CHW | 97 |
| Waters, Drew | KCR | 96 |
| Jones, Nolan | CLE | 86 |
| Hill, Derek | DET | 83 |
| Solak, Nick | TEX | 82 |
| Freeman, Tyler | CLE | 77 |
| Kreidler, Ryan | DET | 73 |
| Leon, Sandy | CLE / MIN | 71 |
| Palacios, Jermaine | MIN | 70 |
| Moreno, Gabriel | TOR | 69 |
| Cameron, Daz | DET | 64 |
| Viloria, Meibrys | TEX | 63 |
| Sano, Miguel | MIN | 60 |
| Contreras, Mark | MIN | 58 |
| Wallner, Matt | MIN | 57 |
| Benson, Will | CLE | 55 |